王文宇

姓名

王文宇

职称

副研究员

层次

博士生导师

招生专业

基础医学(分子医学)

个人简介

中山大学“百人计划”引进人才,博士生导师。中国研究型医院协会病毒肿瘤学专委会委员。2007-2013中国科学技术大学细胞生物学博士。2013-2019新加坡基因组研究院博士后、助理研究员。主要从事肿瘤微环境与肿瘤复发转移、肿瘤免疫逃逸的分子机制及肿瘤靶向/免疫治疗新策略研究。以(共同)第一、通讯作者身份在Nature Medicine、Journal of Experimental Medicine、Cellular & Molecular Immunology、等高水平杂志发表论文多篇,论文他引用1100余次。主持各类科研项目多项,连续获得国家自然科学基金资助4项。

代表成果:
1.Long G, Cheng B, Jiang Y, Liu Q, Huang X, Niu Z, Xiao Q, Qian X, Wei C, Chen J, Weng Y, Zheng Z, Luo D, Ma T, Su T, Tang Q, Wang P, Chen Y, Tan J, Zhang R, Yu Q, Pan W, Wang W. Hepatocyte-derived LRG1 primes the liver for metastasis and impairs immunotherapy. Cellular & Molecular Immunology (IF=19.8),封面, 2026. 

2.Cheng B, Yu Q*, Wang W*. Intimate communications within the tumor microenvironment: stromal factors function as an orchestra. Journal of Biomedical Science (IF=12.1), 2023, 30(1). 

3.Wang W*, Tang Y-A, Xiao Q, Lee WC, Cheng B, Niu Z, Oguz G, Feng M, Lee PL, Li B et al. Stromal induction of BRD4 phosphorylation results in chromatin remodeling and BET inhibitor resistance in colorectal cancer. Nature Communications (IF=15.7), 2021, 12(1):4441-4457. 

4.Wang W, Oguz G, Lee PL, Bao Y, Wang P, Terp MG, Ditzel HJ, Yu Q*. KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer. Journal of Experimental Medicine (IF=10.6), 2018, 215(11):2833-2849. 

5.Goh JY*, Feng M*, Wang W*, Oguz Gokce, Yatim Siti Maryam J M, Lee Puay Leng, Bao Yi, Lim Tse Hui, Wang Panpan, Tam Wai Leong, Kodahl Annette R, Lyng Maria B, Sarma Suman, Lin Selena Y, Lezhava Alexander, Yap Yoon Sim, Lim Alvin S T, Hoon Dave S B, Ditzel Henrik J*, Lee Soo Chin*, Tan Ern Yu*, Yu Qiang*. Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence. Nature Medicine (IF=50.0), 2017, 23(11):1319-1330.

所获荣誉:
1.中山大学附属第六医院先进个人-科研成绩优秀奖,中山大学附属第六医院,2024/2022/2019
2.全国肿瘤标志物TBM青年优秀论文奖,2021
3.中山大学百人计划青年学术骨干,中山大学,2019

邮箱 :wangwy63@mail.sysu.edu.cn